![]() ![]() The study was initiated after Silverman identified a compound, NU-9, developed in his lab for its ability to reduce protein misfolding in critical cell lines. Ryan/Aon Professor of Chemistry at Northwestern. Ozdinler collaborated on the research with study author Richard B. The study will be published in Clinical and Translational Medicine on February 23. "We have identified the first compound that improves the health of upper motor neurons that become diseased." "Even though the upper motor neurons are responsible for the initiation and modulation of movement, and their degeneration is an early event in ALS, so far there has been no treatment option to improve their health," said senior author Hande Ozdinler, associate professor of neurology at Northwestern University Feinberg School of Medicine. So far, there has been no drug or treatment for the brain component of ALS, and no drug for HSP and PLS patients. The disease results in rapidly progressing paralysis and death. ![]() In ALS, movement-initiating nerve cells in the brain (upper motor neurons) and muscle-controlling nerve cells in the spinal cord (lower motor neurons) die. In addition to ALS, upper motor neuron degeneration also results in other motor neuron diseases, such as hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS). ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |